Can Cannabidiol Help Prevent and Treat Gastrointestinal Disorders? Expert Opinions.

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Numerous people look for a “cannabis store near me” to buy marijuana, whether for alleviating a condition or for leisure. It is widely recognized that cannabis products may help in alleviating symptoms like anxiety, depression, pain, nausea, and vomiting. Have you ever thought about its impact on gastrointestinal disorders?

Key Takeaways:

• Cannabinoids in the cannabis plant interact through the endocannabinoid system in the GI tract.
• Cannabis and pain medications can assist in managing Irritable Bowel Syndrome symptoms.
• cannabis serves various purposes, but most people know it for its recreational and medical uses.

Gastrointestinal Disorders and cannabis

The dietary impacts of nutraceuticals on gastrointestinal (GI) health are widely recognized. Specific diets have shown potential in preventing or alleviating various GI issues. Researchers have identified, isolated, and assessed the food components responsible for these benefits.

Among the plant-based nutraceuticals that may aid in treating GI disorders are those derived from cannabis. cannabis refers to products derived from the cannabis Sativa plant, an aromatic annual flowering herb.

John M. McPartland concluded in a scientific review that the Cannabaceae family includes the genera Cannabis, Humulus, and Celtis. Within the cannabis genus, sativa consists of three varieties: Sativa, Indica, and Ruderalis. Depending on the variety, cannabis serves many purposes, including fiber production, oil extraction from seeds, and primarily, recreational or medicinal uses.

The Impact of cannabis

Receptors and ligands of the endocannabinoid system are present throughout various areas and systems, both within and beyond the GI tract, which are crucial for regulating GI functions. The existence of cannabinoid receptors suggests that cannabinoids, including non-psychoactive phytocannabinoids, help modulate GI functions in both health and disease. The ECS plays a role in regulating motility, secretion, epithelial barrier function, and viscerosensitivity.

Irritable Bowel Syndrome (IBS)

IBS has several contributing factors, affecting between 10–20% of individuals in developed countries. It manifests as functional gastrointestinal disturbances without identifiable organic origins.

The amplification of the antinociceptive properties of cannabinoids amid inflammation highlights the importance of the ECS in the development of visceral hypersensitivity. This insight not only illuminates the mechanisms behind conditions like IBS and other gastrointestinal disorders but also suggests promising therapeutic pathways for relieving abdominal and visceral pain.

While cannabinoids alone may not significantly alleviate visceral hypersensitivity in IBS patients, exploring combinations with other pain-modulating agents, like opioids, offers an intriguing alternative worth considering.

Inflammatory Bowel Disease (IBD)

IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), is a complex condition affecting the GI tract, arising from environmental, genetic, and epigenetic factors.

Cannabidiol exhibits strong anti-inflammatory properties across various models of intestinal inflammation in mice and rats, as noted in a study published in the Journal of Frontiers in Pharmacology. Both local and systemic administration of CBD demonstrated a dose-dependent improvement in disease indicators:

• Reduction of structural damage
• Mitigation of inflammation-related increases in cytokines, chemokines, and oxidative stress markers.

A study from the Inflammatory Diseases Journal indicated that a primary finding of their research was the challenging tolerability of the botanical extract, with 90% of patients reporting treatment-related adverse effects compared to 48% receiving the placebo. There was a tendency towards improved quality of life scores and a positive shift in patients’ overall impression of change, according to the per-protocol analysis. The authors speculate that the CBD-rich botanical extract might provide therapeutic benefits to those patients who can tolerate its effects.

Gastrointestinal Cancer

GI cancers, such as colorectal cancer (CRC), rank among the most frequently diagnosed conditions in the general population.

Various studies have demonstrated CBD’s antiproliferative effects in colorectal cancer models. CBD can protect DNA from oxidative stress, boost endocannabinoid levels, and inhibit the proliferation of colorectal cancer cells in vitro.

The confirmation of CBD’s chemopreventive properties emerged from the investigation of in vivo models focusing on AOM-induced colon cancer. A dosage of 1 mg/kg CBD led to a significant reduction: ACF decreased by 67%, while the number of tumors and polyps fell by 66% and 57%, respectively. Increasing the dosage to 5 mg/kg primarily demonstrated effectiveness in preventing polyp formation.

THC induces apoptosis in colorectal cancer cells by activating the CB1 receptor.

Nausea and Vomiting

The positive effects of CBD are amplified when paired with THC, as shown in a study published in the British Journal of Clinical Pharmacology. CBD’s anti-nausea and anti-emetic effects may result from the indirect stimulation of somatodendritic 5-HT1A receptors located in the dorsal raphe nucleus. This activation potentially leads to a reduction in the release of 5-HT in specific forebrain areas.

Gastroesophageal Reflux Disease (GERD)

Cannabinoids inhibit transient LES relaxations through a CB1-dependent mechanism in both dogs and ferrets, as reported in a study from the Journal of cannabis and Cannabinoid Research. These findings are significant as transient LES relaxations are the primary mechanism underlying gastroesophageal reflux disease.

cannabis for GI Issues

Conclusion

Numerous studies suggest that the advantages of cannabinoids extend beyond the well-known psychoactive compound THC to include non-psychoactive molecules like CBD and others, which have not been as thoroughly examined. The cannabis influences the GI system by interacting with the ECS to trigger various functions that can aid in managing symptoms of certain GI disorders.

Frequently Asked Questions

What can you expect when buying from online cannabis stores?

1. Accessing your cannabis products in Canada from an online Coast to Coast Medicinals Canada store provides many options featuring both classic favorites and new products.
2. You can expect additional benefits such as special promotions, reliable payment methods, and shipping options covering most provinces.
3. Essential resources, such as a blog section or contact page, are available to offer customers insights or assistance during their shopping experience.
4. As part of the purchase process, you’ll need to verify or confirm your age by presenting identification.
5. Some stores include taxes on their products in the total price, while others will calculate it at checkout.
6. Some dispensaries accept online payments like Interac E-Transfer, while others allow cash on delivery.

What is the measurement unit when buying from a cannabis website?

There are two primary measurement forms: metric and imperial units. On a cannabis site, you’ll find measurements in grams or ounces, enabling you to locate products like 3.5 grams or 1/8 ounces.

What distinguishes cannabis for medical use from that used recreationally?

Medical cannabis and recreational cannabis originate from the same plant species; however, their different effects and intended uses distinguish them. Medical cannabis serves as a therapeutic aid for specific health conditions, typically containing a higher CBD composition than its recreational counterpart.

Are there ready-made joints available in a cannabis store?

Yes. These are available as pre-rolls. cannabis pre-rolls, or pre-rolled joints and blunts, offer convenient options for those who prefer their cannabis ready for use. The popularity of pre-rolled joints infused with cannabis concentrates is on the rise.

Do cannabis online stores have a physical shop?

Not all online stores maintain physical locations, allowing you to have your purchases delivered directly to your door instead of needing to pick them up from a physical store after placing an order online.

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